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Illustratively, in the mentioned laser-wound studies, human albumin solder supplemented with transforming growth factor (TGF)-1 only, but not with HB-EGF or bFGF, increased the early postoperative strength of laser-welded wounds (Poppas et al., 1996), even though the superpulsed CO 2 laser enhanced fibroblast replication and appeared to stimulate bFGF and inhibit TGF-1 secretion (Nowak et al., 2000)
Key observation: All dose groups began at 0.5mg with gradual escalation over several weeks before reaching maintenance doses
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This creates maximum precision for small doses, making it ideal for microdosing protocols or researchers who prioritize measurement accuracy above all else
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