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Insufficient DAO commonly occurs with gut inflammation, certain genetic variants, or medications that inhibit DAO activity
The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9
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In a particular study, murine subjects were either exposed to Ipamorelin or a control agent
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