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It has been proposed that the allelic variant might influence the stability of GSTP1-1/JNK complex and consequently JNK activity, depending on the redox status of the cell

Tumors with inherited or somatic deficiencies in HRR genes, such as BRCA1, BRCA2, PALB2, and RAD51, exhibit synthetic lethality to PARPis, including olaparib, rucaparib, niraparib, and talazoparib, which have shown durable efficacy in BRCA-mutant breast, ovarian, and prostate cancers

As respiratory care improved and life expectancy rose to roughly 30 years, dilated cardiomyopathy and conduction abnormalities became the primary causes of death in Duchenne

The precedent has been set