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Transcriptional profiling shows altered expression of wnt pathwayand lipid metabolismrelated genes as well as melanogenesis-related genes in melasma
This is a reversible modification and adding sodium borohydride (NaBH4) results in the GSH release, which can subsequently react with DTNB and be measured
Teriparatide has robust human data but is a prescription medication with specific indications and limitations
10.1002/ana.21539 Ann
These therapies can only be used for short periods due to side effects that occur with continuous use, but as a natural molecule, PEPITEM, and the tripeptide sequence that is derived from it are less likely to show these 'off target' effects
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