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Mitochondrial glutamate generated via these catabolic pathways can be exported from mitochondria to the cytosol through the SLC25A18 and SLC25A22 transporters 21 , and cytosolic glutamate then participates in the biosynthesis of glutathionea tripeptide comprising glutamate, cysteine, and glycineand NEAAs (alanine, proline, aspartate, asparagine, and arginine) and is used as an exchange factor for importing extracellular cystine via SLC7A11
Initially developed in the 1960s as a mucolytic agent (1), NAC was later identified as an effective antidote for acetaminophen toxicity by detoxifying N-acetyl-p-benzoquinone imine (NAPQI) (2) (Figure 1)
Urologist Practice Patterns in the Management of Peyronies Disease: A Nationwide Survey
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