The early success of these drugs in combating what was considered to be an intractable public health concern has begun to reshape how society is framing obesity as a health issue, leading to ripple effects that are affecting how food is sold and consumed, insurance and workplace wellness policies, and importantly, public attitudes surrounding the veracity of framing obesity as a medical issue that can and should be treated
In the early stage, inflammation leads to the secretion of inflammatory and pro-degradative mediators, including cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), lipid mediators such as prostaglandin E2 (PGE 2 ), and matrix metalloproteinases (MMPs) by macrophages and fibroblast-like synoviocytes 7,10
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Advances like these remind us that innovation in diabetes care isn't just about developing new drugsit's also about making treatment simpler and improving quality of life for patients