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[ltimo acceso Marzo 2018.] Accesible en: Ficha tcnica de lixixenatida
At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]
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10.3390/biomedicines10051020 16 FabreT.MolinaM
During summer months, when social events, barbecues, and vacations are frequent, they shift their injection day so peak effects cover weekends
