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The dose can be reduced to 50 mg/day if the patient has moderate kidney impairment and further decreased to 25 mg/day in case of severe renal insufficiency
Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NFB activation
The design and application of target-focused compound libraries
[1] However, treatment options for NASH are limited
Dose escalation protocols exist for good reason
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