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Replacement with Tyr 7 lowers both the affinity (IC 50 : 0.26 nM2.7 nM) and activity (EC 50 : 0.8 nM5.4 nM)
The study demonstrated this occurred through direct signaling effects rather than secondary changes from reduced food intake or weight loss
There are also newer delivery methods emerging, including GLP-1 patches and various oral formulations that may suit people who struggled with the injection format
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