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People over 65 or those with lower BMI (27-30 range) may want to consider a more conservative titration schedule, staying at each dose for 6 weeks instead of 4, and possibly targeting 8mg as the maintenance dose rather than pushing to 12mg
Over about six months, people lost an average of 3% of their starting weight
In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )
Avoid sugar alcohols and gums, which can interact with the gut microbiome and lead to bloating
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