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Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: A functional GLP-1-renal axis in man
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Sitagliptin administered to pregnant female rats and rabbits from gestation day 6 to 20 (organogenesis) was not teratogenic at oral doses up to 250 mg/kg (rats) and 125 mg/kg (rabbits), or approximately 30 and 20 times human exposure at the maximum recommended human dose (MRHD) of 100 mg/day based on AUC comparisons
DOI: 10.1017/S0007114526106254)
Peptides were reconstituted in liquid chromatographymass spectrometry-grade water + 0.1% formic acid (vol/vol) via bath sonication for 5 min for a final peptide concentration of 100 ng l 1
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