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The vesicles filled with metabolites release their content into the vacuole or apoplast by a fusion with the respective membranes

Peripherally administered PYY(3-36) crosses the blood-brain barrier to act on Y2R-expressing NPY/AgRP neurons in the hypothalamic arcuate nucleus, inhibiting their activity and enhancing satiety signals (60, 87, 88)

The most common side effects are gastrointestinal adverse effectsnausea, vomiting, diarrhea, and constipationwhich are generally characterized as mild to moderate in severity [20]