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Theoretical considerations suggest fat loss effects should continue as long as the compound is administered, since the mechanism (beta-3 adrenergic lipolysis, lipogenesis inhibition) does not involve receptor desensitization in the way that some hormonal pathways do
Studies have examined the relationship between NNMT inhibition and cellular NAD+ levels, which are critical for numerous enzymatic reactions including those involving sirtuins and PARPs
Rodents have higher metabolic rates relative to body mass, different adipose tissue distribution, and a brown fat compartment that is more metabolically active
For example, an IM injection in the deltoid could hit the radial nerve or artery if placed too low
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