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In a phase 3 clinical trial, people taking 50 milligrams of oral semaglutide lost an average of 15.1% of their body weight in 68 weeks
GLP-1 receptor agonists, including semaglutide, work by slowing stomach emptying and activating satiety signals in the brainmechanisms that can reduce daily calorie intake by 500 calories or more without conscious restriction
One was a 26week trial of liraglutide that found no drop in amyloid levels, but it did find the medication preserved brain glucose metabolism, which is considered a sign of good brain function
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