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doi:10.1152/physrev.1983.63.4.1420

Numerous studies show a positive correlation between the level of TMAO concentration and the onset of several illnesses, including diabetes mellitus, hypertension, ischemic stroke, atrial fibrillation (AF), heart failure (HF), acute myocardial infarction (MI), and chronic kidney disease (CKD) [5]

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This pattern aligns with decades of diabetes research demonstrating that while rapid glycemic improvement carries short-term risks for retinopathy progression, sustained long-term glucose control reduces the incidence and severity of diabetic eye disease

[94] Gastrointestinal side effects, including nausea, abdominal discomfort, and diarrhea, may occur in some patients taking melatonin