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The eight-year regulatory data exclusivity period then ended on January 4, 2026, and a secondary patent covering the injectable formulation expired in March 2026

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Studies show additive increases in circulating GH and IGF-1 levels while preserving natural feedback loops

A study model that monitors blood concentrations of Tirzepatide after its last dose, for example, would provide a scientific basis for determining when its levels are sufficiently low to introduce Retatrutide without significant overlap