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GI side effects in clinical trials typically resolved within 23 weeks, but if symptoms persist beyond four weeks at a reduced dose, discontinuation is warranted

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LCA is particularly harmful due to its ability to form DNA adducts and decrease PARP-1 activity by ~ 40%, impairing DNA repair [43]

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Hypothalamic GPCR signaling pathways in cardiometabolic control

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The enhanced fat oxidation capacity matters most when there is a metabolic demand for it, and physical activity creates that demand much more effectively than caloric restriction alone

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