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Protective effects of the GLP-1 mimetic exendin-4 in Parkinson's disease

Suicidality concerns: what we know now Regulatory reviews by the FDA and EMA have not found evidence that GLP-1s cause suicidal thoughts or behaviors, though monitoring continues (FDA, 2024

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A meta-analysis of 5 RCTs 42,43,44,45,46 comprising 7,732 adults with T2DM did not observe any effect on cognition, as measured via mini-mental state examination (MMSE) or Montreal cognitive assessment (MoCA), of GLP-1RAs over several months compared with the baseline 38