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Macrophages, T lymphocytes, and B lymphocytes in the synovial fluid secrete proinflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor (TNF-), and interleukin-6 (IL-6)

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It increases the availability of arginine for the production of nitric oxide, a molecule which has important functions in the immune system's reaction to infections and that acts as a vasodilator (meaning it helps blood vessels relax)

Last reviewed: July 13, 2026 Last updated: July 13, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations