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Inflammation plays a crucial role in the pathogenesis of atherosclerosis 23,24 , and the observed reduction in CRP levels indicates that GLP-1RAs may reduce systemic inflammation, thereby stabilizing atherosclerotic plaques and reducing the risk of plaque rupture

It's worth noting that this combination carries a lower risk of causing hypoglycemia compared to other diabetes medications [7]

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Conceivably, this effect of SST may, in part, explain the sustained EE observed in the semaglutide-treated mice despite weight loss

Among these major CVOTs, the CAROLINA study compared the cardiovascular safety of linagliptin with that of glimepiride