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IF first increases the abundance of Allobaculum , a genus known to synthesize short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate [107]

58,59 Interactions between innate immune components such as Toll-like receptors (TLRs) and endogenous danger-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns induce nuclear factor-B (NF-B)-mediated inflammation 59 while also promoting renal apoptosis and fibrosis

Oncotarget 2017;8:6420316

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When deep sleep suffers from stress, aging, chronic pain, or hormonal decline GH production plummets