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GHK-Cu acts at the extracellular matrix (ECM) level, modulating the balance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) to regulate collagen turnover, and stimulating fibroblasts to produce collagen type I, collagen type III, and elastin

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doi: 10.1016/S0140-6736(21)00213-0 21 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al

Patients who run a protocol for four weeks and stop typically do not see the changes that show up later in the timeline