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Primary biochemical, adipocyte, selectivity, permeability, and mouse proof-of-concept study
The fragment retains the ability to stimulate fat breakdown and inhibit lipogenesis in adipocytes, pathways attributed to interaction with the beta-3 adrenergic receptor in animal models (Heffernan et al., 2001, Journal of Endocrinology)
Even at high doses, studies have consistently revealed little to no toxicity or negative effects linked with the administration of BPC-157
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