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This shift becomes even more delicate when we factor in physical side effects like nausea or reflux

2 Prioritize Protein Intake To counteract muscle loss, increase protein intake to at least 1.6-2.2g per kg of body weight daily (slightly higher than usually prescribed because of the faster breakdown)

This pattern is reported across forums and is consistent with IGF-1's known effects on intracellular hydration and protein synthesis through PI3K/Akt/mTOR (Yoshida & Delafontaine, 2020)

Patients who benefit most include those with a history of repeated dieting failures, strong food cravings or binge patterns, emotional eating, insulin resistance, or constant food noise interfering with daily life

The reason the gap matters is tolerability as much as efficacy