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Nutritional deficiencies may also play a role, particularly in patients experiencing significant gastrointestinal side effects

The M6 study (Macrovascular and Microvascular Morbidity and Mortality after Metabolic Surgery versus Medicines) tracked 3,932 adults with obesity and diabetes who received care at Cleveland Clinic for up to a decade

6 Results from a systematic review and meta-analysis study showed that following discontinuation of weight management medications: Patients are estimated to return to baseline weight within 1.7 years 1,** Results from that same study also highlighted that following discontinuation of weight management medications: Cardiometabolic benefits may be lost, with markers estimated to return to baseline within 1.4 years 1,** Ongoing obesity treatment is needed for maintaining weight loss and improvements in cardiometabolic markers 4 Addressing Discontinuation Starts With Understanding What May Influence Adherence and Persistence 5 Long-term adherence is shaped by multiple, interconnected factorsand ongoing research continues to explore how challenges may interact over time

PMID: 16987039 | DOI: 10.1089/ars.2006.8.1865 [2] Erden-Inal M, Sunal E, Kanbak G