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Whole tumors were evaluated for staining intensity and distribution of stained cells
The failure of the antioxidant system to negate the pathological rise in the oxidative species is exacerbated by reduction in levels of the major cellular nucleophile, GSH due to their covalent modification by dopamine quinone species 20,43,44,45
Acknowledgements This work was partially supported by grants from JSPS (KAKENHI Grant Numbers JP21K08032 and 24K11270) to KS
The researchers noted that while weight loss likely drives much of the testosterone improvement, the lack of a significant association between the degree of weight loss and testosterone change in some analyses suggests additional mechanisms may be at work
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