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Hyperandrogenism in PCOS alters the gut microbiota composition by promoting mucus-degrading bacteria (such as Ruminococcus ), while depleting butyrate-producing bacteria (like Faecalibacterium ), thereby exacerbating intestinal barrier dysfunction (38)

Its inclusion reflects its standing in the industry, though it sits outside the reach of typical research procurement

This stands in stark contrast to growth hormone, which typically worsens insulin sensitivity during treatment

10.3390/cells10112835 35 FoxJ

When portal insulin levels are low (e.g., during fasting and in T1DM), the low insulin activity in the liver must be able to lower IGF-1 secretion and reduce its activity to prevent IGF-1-induced hypoglycemia by binding to the INSR, as the IGF-1 concentrations are significantly higherenough to compensate for the lower affinity of IGF-1 to the INSR