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High expression of GT provides cells with greater quantities of cysteine through the breakdown of extracellular GSH (Gerber and Thung, 1980

Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells

The theory that considers hyperlipidemia as a primary cause of B-cell dysfunction instead of hyperglycemia [26] (as it is reported that elevated free fatty acids and other lipids can impair B-cell function) is corroborated by the findings that GSTM1 does not influence the risk of T2DM but instead alters glycemic control along with GSTT1 polymorphism association with increased susceptibility to T2DM with only an alteration to lipid metabolism

The fat-soluble derivative Benfotiamine can be a more effective form for addressing depletion

References Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH