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Higher doses were associated with increased sensory effects and higher discontinuation rates

[56] [57] Economic evaluations of GLP-1 receptor agonists for non-diabetic obesity have reported incremental cost-effectiveness ratios well above common willingness-to-pay thresholds, including estimates in the approximate range of $237,000-$483,000 per quality-adjusted life-year in some U.S.-based models

In severe cases, skin and underlying tissue can suffer necrosis (tissue death), requiring antibiotics or surgery to treat

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Key therapeutic areas include diabetes management, cancer treatment, cardiovascular disease, rare genetic disorders, and tissue repair applications