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While some individuals may notice changes within the first few weeks of treatment, significant effects usually become apparent after three to four months

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Another study focusing on individuals taking a 2.4 mg dose of semaglutide found that those who experienced diarrhea only dealt with the symptoms for about three days

AGT is present in the proximal tubule and concurrent increases in AGT-mRNA/protein in renal tissue homogenates has been explained as indicating that transcriptional activation of the AGT gene would be responsible for renal ANG II increase