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This occurs because tirzepatide reduces appetite and improves insulin sensitivity through GLP-1 and GIP receptor activation, and these effects diminish once the medication leaves your system
doi: 10.1186/s40164-020-00196-w 120 WangQLibertiMVLiuPDengXLiuYLocasaleJWet al
The priority is to keep levels stable or rising, not to trim back supplementation
Tirzepatide was originally approved by the FDA in 2022 under the brand name Mounjaro to help control blood sugar in Type 2 diabetes
PMID 22279102
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