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In obese mice, MR (.12%) increased FGF-21 levels and was more resistant to glucose and insulin (Purushotham et al., 2009)

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The brand-name oral pill has run roughly $149 to $299 per month through manufacturer self-pay channels, making it the lowest-cost FDA-approved path for most cash payers

The same dynamic appears in airlines, telecommunications, and high-value manufacturing sectors ranging from steel to semiconductors

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