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Their primary mechanisms of action include: Stimulating insulin secretion in a glucose-dependent manner (reducing hypoglycaemia risk) Suppressing glucagon release when blood glucose is elevated Slowing gastric emptying, which prolongs satiety Acting on appetite centres in the brain to reduce food intake Common GLP-1 medicines available in the UK include semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity)

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Age Ageing 50 , 21832191 (2021)

GLP-1 has been shown to impair gallbladder motility and contractility by inhibiting cholecystokinin secretion

Reduces Food Cravings Especially cravings for sweets and processed foods