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Animal model research reveals remarkable efficacy in both accelerated and natural aging conditions, with XpdTTD/TTD mice (accelerated aging model) showing restoration of multiple age-related deficits including fitness, fur density, and renal function following FOXO4-DRI administration

One difference, though, is that at younger ages PDH activity was significantly higher in Glyco Hi mice, suggesting over a longer time period compensatory mechanisms may limit the activity of this key regulator of glucose oxidation

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Yes, there is still the need for some alcohol - hence the acids in here, but you will not feel dry at all

Presented for research literature review only de los Reyes B et al