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Furthermore, loss of lean muscle mass, which can occur alongside fat loss if protein intake and resistance exercise are inadequate, further reduces metabolic heat production since muscle tissue is metabolically active and generates significant body heat even at rest

In patients with T2D who need greater glucose lowering than can be obtained with oral agents, GLP-1 RAs are preferred to insulin when possible

Lilly's oral GLP-1, orforglipron, demonstrated statistically significant efficacy results and a safety profile consistent with injectable GLP-1 medicines in successful Phase 3 trial Orforglipron is the first small molecule GLP-1 to successfully complete a Phase 3 trial, lowering A1C by an average of 1.3% to 1.6% across doses The investigational once-daily oral pill reduced weight by an average 16.0 lbs (7.9%) at the highest dose in a key secondary endpoint The overall safety and tolerability profile of orforglipron in ACHIEVE-1 was consistent with injectable GLP-1 therapies 1 "ACHIEVE-1 is the first of seven Phase 3 studies examining the safety and efficacy of orforglipron across people with diabetes and obesity

Patients value O3 Plus for its personalized care model, meticulous protocols, and commitment to safety

(PubMed) Wu D, Meydani SN