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Int J Mol Med (2015) 36(1):17385
These early changes dont always require surgery
This was reproduced in a companion experiment with semaglutide and MAR709, another GLP-1/GIP dual agonist
What survives that test is narrower and more testable than the broad claim it replaces: that brain-penetrant agonism, delivered early, in patients chosen by their biology rather than their diagnosis, and judged against biomarkers rather than questionnaires, might still work
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