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It can't build muscle without amino acids
liver glucose production decreases22 and intestinal glucose uptake increases, acting as a hyperglycemia clearance mechanism in diabetes.23 The effect of metformin on body weight is neutral, though in some cases it induces modest weight loss.24 While it is a safe drug, its gastrointestinal side effects appear to be underestimated in the literature.4 Gradual dose titration and administration with food is advised in order to improve tolerance of this drug
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Afamelanotide (Scenesse): FDA-approved MC1R agonist for erythropoietic protoporphyria
These findings support the safety and potential disease-modifying effects of FUS-mediated BBB opening in early-stage AD, although larger trials are warranted to establish clinical efficacy (Rezai et al., 2024)
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