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Cellular effects duration vs plasma half-life Critical distinction: Plasma half-life duration of effects GHK-Cu clears blood in hours But cellular effects last days How GHK-Cu works: Peptide binds to cell surface receptors Triggers intracellular signaling cascades Activates gene expression changes Initiates collagen synthesis, wound healing, etc

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J Appl Toxicol 6(5):363370 Gray BH, Porvaznik M, Flemming C, Lee LH (1987) tri- n -Butyltin: a membrane toxicant