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PD actually involves dysfunction in dopamine metabolism in many parts and regions of the brain, including synthesis, secretion, transport, reuptake, elimination, and receptor binding of DA (16)

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Mol Neurobiol (2018) 55(5):403050

Recent advances have focused on overcoming the limitations of PEGylation, often referred to as the PEG dilemma, where the PEG layer extending circulation time can hinder cellular uptake at the target site