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This is thought to be because these medications impact the brains hypothalamus, which is basically the brains control center because it regulates mood, hunger, thirst and body temperature

Presented for research literature review only Karsten WE et al

An endogenous TLR4 ligand HMGB1 drives age-related cardiac dysfunction through TLR2/TLR4-mediated M1 macrophage polarization in senescence-accelerated-prone (SAMP8) mice, whereas TLR4 deletion prevents extracellular HSP27-mediated injury despite age-related TLR4 upregulation and NF-B hyperactivation, revealing TLR4 as a therapeutic target [320, 321]

Not surprisingly, this has led to a worldwide shortage in these medications, such as Ozempic, Mounjaro, Trulicity, and Rybelsus, over the last two years

The FDA labeling includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, though the relevance to humans remains uncertain