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DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood, studied in neuroregulatory and sleep architecture research models since the 1970s

This points to the hypothesis that chronic hyperglycemia in diabetes, along with dysregulated central sensing of glucose concentrations in diabetics, may impair central transport of GLP-1 receptor agonist and explain the reduced efficacy for weight loss in type two diabetic patients. Geisler also discussed astrocytes

doi: 10.3760/cma.j.issn.0366-6999.2012.08.018 99 ZhuTWuXLZhangWXiaoM

The critical pattern to watch is escalation over weeks rather than an isolated flare after a large meal