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for more details, see Sampson et al., 2021 13
PT-141 was developed to interact primarily with the Melanocortin-4 Receptor (MC-4R), although other melanocortin receptors (MC-1R, MC-2R, MC-3R, and MC-5R) may also play varying roles in physiology
It is not typically successful, but each case is unique
These are usually tolerable and improve as the body adapts
In melanoma patients refractory to antiPD-1 therapy, the combination of Talimogene laherparepvec (T-VEC), an oncolytic herpesvirus, with pembrolizumab (NCT04068181) showed enhanced systemic immune activation and tumor response
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