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In skeletal muscle, they downregulate atrophy-associated genes (MuRF1, MAFbx) and upregulate myogenic factors (MyoD, MyoG), thereby improving perfusion and energy metabolism
Whereas GLP-1 decreases plasma glucose levels by exerting insulinotropic effects, glucagon stimulates hyperglycemia by enhancing hepatic glucose output
doi: 10.1590/s1984-82502011000100023 109 GrujoviMSemedo-LemsaddekTMarkoviKG
So unless you include regular exercise as part of your weight loss program, the weight you lose while taking Ozempic, Wegovy, Mounjaro or Zepbound will include both muscle and fat, but the weight you will regain after stopping the GLP-1 will be mostly fat, leaving you metabolically even worse off than when you started