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Retatrutide is still investigational and only available in clinical trials

The Bottom Line The level of difficulty in the modern launch environment is unforgiving

If the side effects are severe or do not go away, consult with your doctor

Heart Health Semaglutide, the active ingredient in Rybelsus, has been shown to reduce the risk of major cardiovascular events, including heart attacks and strokes

Classic Symptoms Polyuria: frequent urination Polydipsia: increased thirst Polyphagia: increased hunger Fatigue and blurred vision may also occur Many patients are diagnosed during routine screening Metabolic Features Central obesity is common Insulin resistance is the major underlying problem Metabolic syndrome often coexists Hypertension and dyslipidemia are frequently present Skin Clues Acanthosis nigricans at neck and axilla suggests insulin resistance Skin tags may be present Recurrent skin infections can occur in poorly controlled disease Microvascular Complications Retinopathy: blurred vision, retinal damage in long-standing disease Nephropathy: microalbuminuria is an early sign