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The mechanistic rationale for GIPR agonism alongside GLP-1R agonism was initially counterintuitive, given that GIP had been considered therapeutically inert in T2DM due to documented GIP resistance
23 Consider adding GLP-1A before using insulin or as an insulin sparing agent in patients already on insulin, particularly in those at high ASCVD risk
However, patients should verify individual provider qualifications, as telehealth platforms vary in the depth of subspecialty training or obesity-medicine certification among their networks
Studies also suggest effects on angiogenesis, growth hormone receptor expression, and nitric oxide pathways
As an amino acid, it acts as a stabilizer that helps maintain the peptide structure of tirzepatide during storage and transport
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