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The limitations of oral glutathione include absorption challenges and mild adverse effects

This has implications for how to design human albumin-fused biologics, as QMP engineering may ensure a long plasma half-life, increased target exposure, and enhanced efficacy, despite potential C-terminal cleavage post-administration

However, the direct antioxidant activity may occur through breaking disulfide bonds, which is what it does in the lungs to break up mucus

[1] The FDA prescribing information does not specify a required washout period before conception, so women should consult with their healthcare provider about appropriate timing