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d Thrombotic microangiopathy (TMA) Undiagnosed thrombotic thrombocytopenia purpura (TTP), a form of TMA, has a mortality of up to 90%

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Food and Drug Administration (FDA) recommends that metformin be used only in patients with an estimated glomerular filtration rate of 30 mL/min/1.73 m2 or greater (4)

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A drugs packaging can also affect its shelf life and the chemical stability of the medication

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de la Cuesta-Zuluaga et al., 2017

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It has an excellent safety profile when used at recommended doses (maximum 4 g daily in divided doses for adults

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