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There have been no reported safety concerns, no significant drug-related adverse events, no deaths, and no adverse events leading to discontinuation of a study [8, 9, 10, 11, 12, 13, 14, 15]

UK regulatory status retatrutide holds no MHRA marketing authorisation and is supplied for laboratory research use only as of 2026

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211 A recent randomized controlled trial involving patients with heart failure with preserved ejection fraction and obesity demonstrated that 52 weeks of treatment with tirzepatide not only improved patient health status but also reduced the risk of a composite endpoint of cardiovascular death or worsening heart failure

For those who werent comfortable with weekly injections, a once-daily pill is much easier to use and understand, he said