The STEP clinical trials showed that semaglutide at higher doses (2.4 mg, marketed as Wegovy) led to roughly 15% body weight reduction, while real-world data on metformin shows an average of about 5% reduction
Ozempic and Sex: The Surprising Sexual Side Effects of GLP-1s You may notice changes to your sexual performance and love life if you take glucagon-like peptide-1 (GLP-1) agonists such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepound, Mounjaro)
Zepbound (Tirzepatide) Zepbound offers an advanced option, targeting both GLP-1 and GIP hormones to enhance weight loss
This translated to a mean weight loss of 4.7 kg for those on tirzepatide during the same period
Studies show the combination accelerates healing of gastric ulcers, reduces inflammation in inflammatory bowel disease models, restores gut barrier function, and may protect against various toxins