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FOXO4p53 disruption Frees p53 to act in senescent cells

In an MPTP-induced mouse model of PD, oral administration of total flavonoids of Astragalus (TFA) increased GPX4 expression, elevated GSH levels, reduced ROS production, and suppressed neuronal ferroptosis (Gao et al., 2024)

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Targeting Glutathione S-transferase M4 in Ewing sarcoma [PMID: 25147782] Laboratory literature summary: Targeting Glutathione S-transferase M4 in Ewing sarcoma